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Don't let travelers' diarrhea (TD) ruin your trip.

Pack aemcolo to help treat the infection.

Please see full prescribing information for AEMCOLO (rifamycin)
and IMPORTANT SAFETY INFORMATION below.

What is AEMCOLO?

The 1st FDA-approved antibiotic for the treatment of travelers' diarrhea (TD) in over a decade!

AEMCOLO is for the treatment of adults with travelers' diarrhea caused by certain types of bacteria called E. coli.

It fights the germs that often cause TD in adults (noninvasive strains of E. coli) which helps relieve symptoms – in fact most people notice improvement by the second day, and some even notice their diarrhea becoming less frequent the day they start AEMCOLO. That said, it's important to remember that, although you may feel better early in the course of therapy, you must continue to take AEMCOLO and complete the full 3-day course.

AEMCOLO is not for travelers who have a fever and/or blood in their diarrhea.

Do not take AEMCOLO if you have a known allergy to rifamycin or any other rifamycin antibiotics or any of the components in AEMCOLO.

Package of the FDA-approved antibiotic AEMCOLO ready to be packed in a travelers'   checked luggage
Couple in their 30's enjoying a vacation and feeling prepared for travelers' diarrhea because they packed AEMCOLO

How does it work?

AEMCOLO helps fight the
infection at its source

AEMCOLO has a targeted delivery system designed to work in the colon, where TD strikes. It's also a minimally absorbed antibiotic, so it stays where it's needed in your body to help fight the infection at its source.

The most common side effects while taking AEMCOLO are constipation and headache.

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Why worry about travelers' diarrhea (TD)?

According to the CDC, if TD strikes, you should be ready to strike back by carrying an antibiotic when you travel.

An adventure trek in Africa or a Caribbean cruise with family both sound amazing, but what happens if you get infected with TD? Imagine yourself enjoying your trip and then diarrhea suddenly strikes and you get hit with painful cramps, nausea and an urgent need to run to the toilet. Not so amazing anymore – especially if it lasts for your entire trip!

And if your next business trip is somewhere in Asia or South America, bet you aren't planning to take any important calls from the restroom!

African safari with giraffes ruined by painful travelers' diarrhea symptoms and a frequent urge to use the toilet

Travelers' diarrhea (TD) can be caused by viruses and parasites, but is most often caused by a bacteria you may have heard of called E. coli. This bacteria has to be ingested, and is usually in contaminated food or drink. It's as simple as a cook preparing your meal without washing their hands after going to the restroom. Sounds gross, doesn't it? But it happens more often than you think.

Chef with poor hygiene habits possibly contaminating food with <em>E. coli</em> after using the toilet and not washing her hands

Poor hygiene and improper food handling are some of the most common ways TD is spread.

e-coli-stamp_text e-coli-stamp_cercle

Travelers' diarrhea (TD) usually starts suddenly during a trip – and can even strike more than once on the same trip. Unpleasant and painful symptoms can kick in a few hours after you've been infected, and may include:

Traveler missing out on his trip because of sudden travelers' diarrhea and an urgent need to use the toilet in a remote area
  • an urgent need to go to the bathroom
  • diarrhea that interferes with your daily plans
  • painful cramping
  • explosive and painful gas
  • nausea
  • vomiting

Left untreated, TD symptoms can last your ENTIRE TRIP, and even come home with you!

Where in the world is travelers' diarrhea (TD) a risk?

Up to 70% of
travelers get TD

If you've traveled abroad, maybe you've already experienced TD at some point. And if you haven't, think of yourself as a lucky traveler because TD is more common than you think. In fact, it's one of the most common travel-related illnesses out there.

Each year, TD strikes millions of international travelers. So where in the world are these people going? According to the Centers for Disease Control (CDC), the world is divided into 3 levels of risk for getting TD: low, medium and high.

When you look at the map, it's pretty clear that wherever you plan to travel you may be at risk for TD – because even a low- or medium-risk destination could be where TD strikes and ruins your trip. If you're planning to travel soon, it's a good idea to understand your risk for TD and how to plan ahead. That way you can cut your TD short and not your trip!

TD Risk Map
Map of the world showing countries and their travelers’ diarrhea risk, with the low-risk zones of Canada, the U.S., Australia, New Zealand and Western Europe, the medium-risk countries of Eastern Europe (Bulgaria, Czech Republic, Hungary, Moldova, Poland, Romania, Russian Federation, Slovakia, Ukraine), Japan, and South Africa, and the high-risk countries of Africa (Algeria, Angola, Benin, Botswana, Burkina Faso, Burundi, Cabo Verde, Cameroon, Central African Republic, Chad, Comoros, Congo, Cote d’Ivoire, Democratic Republic of Congo, Djibouti, Equatorial Guinea, Eritrea, Ethiopia, Gabon, Gambia, Georgia, Ghana, Guinea, Guinea Bissau, Kenya, Lesotho, Liberia, Libya, Madagascar, Malawi, Mali, Mauritania, Mauritius, Morocco, Mozambique, Namibia, Niger, Nigeria, Rwanda, Sao Tome & Principe, Senegal, Seychelles, Sierra Leone, Somalia, South Sudan, Sudan, Suriname, Swaziland, Tanzania, Tunisia, Timor-Leste, Togo, Uganda, Zambia, Zimbabwe), Asia (Afghanistan, Armenia, Azerbaijan, Bangladesh, Bhutan, Brunei, Cambodia, China, India, Indonesia, Kazakhstan, Kyrgyzstan, Laos, Malaysia, Maldives, Mongolia, Myanmar, Nepal, North Korea, Philippines, South Korea, Sri Lanka, Taiwan, Tajikistan, Thailand, Turkmenistan, Uzbekistan, Vietnam), the Caribbean (Anguilla, Antigua and Barbuda, Aruba, Barbados, Belarus, British Virgin Islands, Caribbean Netherlands, Cayman Islands, Curaçao, Dominica, Dominican Republic, Grenada, Guadeloupe, Guyana, Haiti, Jamaica, Martinique, Montserrat, Puerto Rico, Saint Barthelemy, Saint Lucia, Saint Martin, Saint Kitts and Nevis, Saint Vincent and the Grenadines, Saint Maarten, Trinidad and Tobago, the Bahamas, Turks and Caicos Islands, United States Virgin Islands), Central and South America (Argentina, Belize, Bolivia, Brazil, Chile, Colombia, Costa Rica, El Salvador, Ecuador, Guatemala, Honduras, Nicaragua, Panama, Paraguay, Peru, Uruguay, Venezuela), Mexico, and the Middle East (Bahrain, Cyprus, Egypt, Iran, Iraq, Israel, Jordan, Kuwait, Lebanon, Oman, Palestine, Pakistan, Qatar, Saudi Arabia, Syria, United Arab Emirates, Turkey, Yemen).

Adpated from Steffen et al.

  • Low risk
  • Medium risk
  • High risk
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Group of friends having fun and not missing out on their trip because they prepared for travelers' diarrhea

FAQs

TD is one of the most common travel-related illnesses. It usually starts suddenly during a trip, with unpleasant and painful symptoms that include an urgent need to go to the bathroom, watery diarrhea, painful cramping, explosive and painful gas, nausea and vomiting. It can last up to a week or more.

TD can be caused by viruses and parasites, but is most often an infection caused by a bacteria called E. coli. This bacteria has to be ingested, and is usually in contaminated food or drink. Poor hygiene and improper food handling are some of the most common ways TD is spread.

AEMCOLO is an antibiotic that has been shown to be effective against bacteria that commonly cause TD (E. coli). A 3-day course of AEMCOLO is recommended to treat the infection that is causing TD symptoms.

The CDC recommends that you use an antibiotic like AEMCOLO for moderate or severe diarrhea, which are defined as follows:

Moderate: Diarrhea that is distressing or interferes with your daily planned activities.
Severe: Diarrhea that is incapacitating or completely prevents you from participating in your planned activities.

Take AEMCOLO only after diarrhea symptoms begin, and you strongly suspect they are caused by a bacterial infection. AEMCOLO should always be taken as directed by your physician.

AEMCOLO is not recommended for use in patients with diarrhea accompanied by fever or bloody stools. Stop taking AEMCOLO if diarrhea gets worse or lasts more than 48 hours and notify your healthcare provider.

AEMCOLO is not for everyone. Do NOT take AEMCOLO if you have a fever and/or blood in your diarrhea. Do not take AEMCOLO if you have a known allergy to rifamycin or any other rifamycin antibiotics or any of the components in AEMCOLO. AEMCOLO is not recommended for use in patients with diarrhea accompanied by fever or bloody stools. If you experience a fever and/or blood in your diarrhea, please contact a local physician.

Not easily. You can still do everything right – wash your hands, avoid street food, drink bottled water, etc. – but it only takes one contaminated bite or sip to ruin your trip. Unfortunately, you won't be able to tell which bite or sip is the one that infects you ahead of time. Just ask the over 15 million people a year who get TD.

Untreated, TD can last up to a week or longer. Treatment with an antibiotic like AEMCOLO can help reduce the length and severity of TD, and may help prevent possible complications after the infection is gone.

Click the 'Start consult' or 'Start your consultation' buttons on this site, and you will be taken to a telemedicine site.

The site makes it very easy for you to consult with a medical prescriber online. Based on your consultation, you may be prescribed AEMCOLO and can have the prescription delivered straight to your door in 3 easy and convenient steps:

1. Register for a consult with a telemedicine provider
2. Complete a quick questionnaire and consult with a medical prescriber
3. Pay for your telemedicine consult

If AEMCOLO is right for you, your prescription will be charged to your payment information and AEMCOLO will be shipped to your home.* Sounds pretty simple, doesn't it? No need to drive anywhere, take time off work, or talk your parents into babysitting the kids!

*Some restrictions may apply

Several medications are available to help reduce and relieve TD symptoms, including:

  • • Fluid replacement
  • • Anti-motility/diarrhea agents
  • • Neutralizing agents
  • • Dietary supplements

Only antibiotics, like AEMCOLO, help treat the infection that causes TD and its symptoms.

Indication and Important Safety Information

What is AEMCOLO used for?
AEMCOLO is for the treatment of adults with travelers' diarrhea caused by certain types of bacteria called E. coli, which is not complicated by a fever or blood in the stool.

Who should NOT take AEMCOLO?
AEMCOLO is not for everyone. Do not take AEMCOLO if you have a known allergy to rifamycin or any other rifamycin antibiotics or any of the components in AEMCOLO. You should not use AEMCOLO if you have a fever and/or bloody diarrhea.

What WARNINGS and IMPORTANT INFORMATION should I know about AEMCOLO?
Stop taking AEMCOLO if diarrhea gets worse or lasts more than 48 hours and notify your healthcare provider.

With all antibiotics, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C. difficile). This can cause signs of disease ranging from mild diarrhea to life-threatening disease of the bowel.

AEMCOLO safety and how well it works in children less than 18 years old has not been studied. AEMCOLO does not treat viral infections (for example, common cold or flu).

How should I take AEMCOLO?
The usual dose is 388 mg (2 tablets) by mouth 2 times a day (in the morning and evening) for 3 days.

  • AEMCOLO tablets should be swallowed whole with a full glass of liquid (6-8 ounces).
  • AEMCOLO must not be taken at the same time with alcohol.
  • AEMCOLO tablets must not be chewed, crushed, or broken.
  • AEMCOLO may be taken with or without food.

When taking AEMCOLO for an infection due to bacteria, it is common to feel better before the antibiotic therapy is finished. It is important to take the antibiotic exactly as directed. Do not skip doses or end before all the medication is taken. If you do, you may lower how well the drug will work and may increase the chance of the bacteria becoming resistant.

What are the most common side effects of AEMCOLO?
The most common side effects (occurrence >2%) while taking AEMCOLO are:

  • Constipation (3.5%)
  • Headache (3.3%)

These are not all the possible side effects of AEMCOLO. Tell your doctor if you have any side effects that bother you or do not go away. Call your doctor for medical advice about side effects.

You can also report any side effects to Aries Pharmaceuticals Inc. at 1-888-274-3708 or by contacting the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

AEMCOLO Full Prescribing Information
1-AEM19045

You can report any side effects to Aries Pharmaceuticals Inc. at
1-888-274-3708 or by contacting the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

What is AEMCOLO used for?
AEMCOLO is for the treatment of adults with travelers' diarrhea caused by certain types of bacteria called E. coli, which is not complicated by a fever or blood in the stool.

Who should NOT take AEMCOLO?
AEMCOLO is not for everyone. Do not take AEMCOLO if you have a known allergy to rifamycin or any other rifamycin antibiotics or any of the components in AEMCOLO. You should not use AEMCOLO if you have a fever and/or bloody diarrhea.

What WARNINGS and IMPORTANT INFORMATION should I know about AEMCOLO?
Stop taking AEMCOLO if diarrhea gets worse or lasts more than 48 hours and notify your healthcare provider.

With all antibiotics, there is a chance you could experience diarrhea caused by an overgrowth of bacteria (C.difficile). This can cause signs of disease ranging from mild diarrhea to life-threatening disease of the bowel.

AEMCOLO safety and how well it works in children less than 18 years old has not been studied. AEMCOLO does not treat viral infections (for example, common cold or flu).

How should I take AEMCOLO?
The usual dose is 388 mg (2 tablets) by mouth 2 times a day (in the morning and evening) for 3 days.

  • AEMCOLO tablets should be swallowed whole with a full glass of liquid (6-8 ounces).
  • AEMCOLO must not be taken at the same time with alcohol.
  • AEMCOLO tablets must not be chewed, crushed, or broken.
  • AEMCOLO may be taken with or without food.

When taking AEMCOLO for an infection due to bacteria, it is common to feel better before the antibiotic therapy is finished. It is important to take the antibiotic exactly as directed. Do not skip doses or end before all the medication is taken. If you do, you may lower how well the drug will work and may increase the chance of the bacteria becoming resistant.

What are the most common side effects of AEMCOLO?
The most common side effects (occurrence >2%) while taking AEMCOLO are:

  • Constipation (3.5%)
  • Headache (3.3%)

These are not all the possible side effects of AEMCOLO. Tell your doctor if you have any side effects that bother you or do not go away. Call your doctor for medical advice about side effects.

You can also report any side effects to Aries Pharmaceuticals Inc. at 1-888-274-3708 or by contacting the FDA at 1-800-FDA-1088 or www.fda.gov/medwatch.

AEMCOLO Full Prescribing Information
1-AEM19045